DUOTROL 5 MG/500 MG TABLET

Talk to Doctor

Tell your doctor before taking this medicine, if you:
- are allergic (hypersensitive) or any of the other ingredients of this medicine
- are undergoing Electroconvulsive therapy (ECT)
- have suffered from abnormally elevated mood (mania) in the past
- have any liver or kidney problems
- suffer from congenital heart defect
- have diabetes
- have a history of bleeding disorders
- have raised intraocular pressure or are at risk of acute narrow-angle-glaucoma
- are depressed or have anxiety disorders you can sometimes have thoughts of harming or killing yourself
- are an alcoholic

Pregnancy & Breast Feeding
- Caution should be exercised when used during pregnancy, especially during late pregnancy or just before giving birth
- This medicine is excreted in breast milk and may cause side effects in babies
- Talk to your doctor as soon as possible if you are pregnant or might be pregnant, planning to become pregnant or breast feeding

Children & Adolescents
- You should not be used in children and adolescents under the age of 18


Driving & Using Machines
- Do not drive or use machinery unless you are sure that you are not affected

Duotrol Tablet is a combination of two antidiabetic medicines: Glibenclamide and Metformin. Glibenclamide is a sulfonylurea which works by increasing the amount of insulin released by the pancreas in order to lower the blood glucose. Metformin is a biguanide which works by lowering glucose production in the liver, delaying glucose absorption from intestines and increasing the body's sensitivity to insulin.

Serious

Like all medicines, this medicine can cause side effects, although not everybody gets them.

- allergic reaction such as rash, itching, swollen lips, tongue or face, wheezing or shortness of breath
- faster breathing or heart rate, sweating, muscle stiffness or tremor, confusion, extreme agitation or sleepiness
- prolonged and painful erection
- irritability and extreme agitation
- heart problems, such as fast or irregular heart rate, fainting, collapsing or dizziness upon standing which may indicate abnormal functioning of the heart rate
- inexplicable vaginal bleeding
- inexplicable bruises or bleeding or bleeding in the gastrointestinal tract
- fits
- uncontrollable movements
- signs of liver inflammation (abdominal swelling, distention or bloating, diarrhoea, discolored urine and stool, fatigue, headache, itchy skin, joint pain, loss of appetite, low-grade fever, malaise and lethargy, nausea with or without vomiting, yellowing of the skin and whites of the eye)
- small bleedings of skin and mucosa, painless (rarely itching) skin swelling, acute, inflammatory skin disease, heavy skin reactions Stevens-Johnson Syndrome, erythema multiforme, toxic epidermal necrolysis (Lyell syndrome)

Common
Like all medicines, this medicine can cause side effects, although not everybody gets them.

- poor appetite
- change in taste
- nervousness, anxiety
- feeling tensed
- decreased sex drive or sexual difficulties (including low sexual performance and ejaculation problems)
- sleep problems or unusual dreams
- tremor
- drowsiness
- blurred vision
- flushing
- yawning
- indigestion, vomiting
- joint pains
- passing urine too frequently
- feeling shaky or chills
- weight loss
- headache, dry mouth

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Duotrol Tablet is to be taken with food.

- Keep this medicine out of reach of children
- Do not use this medicine after the expiry date